Blastomyces in a dog

Summary: A 7-year-old, intact male, German Shorthaired Pointer was submitted to ADDL following an acute history of respiratory distress, prostatomegaly, tenesmus, and anorexia.  At necropsy, the lungs were dark red and non-collapsing with multifocal to coalescing, gray nodules widely disseminated throughout all lung lobes.  The prostate gland was expanded by abundant pale tan soft tissue.  Histologically, the lung and prostate were expanded and infiltrated by granulomatous inflammation with intralesional fungal yeasts, morphologically consistent with Blastomyces spp.

Numerous thick-walled, buff-colored, spherical to ovoid, broad-based budding yeasts are scattered throughout granulomatous inflammation in the prostate gland and lung.  The yeasts measure approximately 5-20 µm in diameter; findings are consistent with Blastomyces spp.