Toxicology/Analytical Chemistry
General Guidelines for Toxicology/Analytical Chemistry Submissions
  • Please complete an appropriate Submission Form, available on the Forms page, and submit with sample.
  • Refrigerate or freeze tissue samples.
  • Test requests must be specific. If you are unsure of what test to request, call the Toxicology Laboratory prior to sample submission.
  • Samples will be held for 2 weeks past the final report date of Toxicology testing. Please notify the Toxicology Laboratory as soon as possible to request additional testing.
Suspected Toxicoses of Unknown Origin
When a toxicosis is suspected, but the specific toxin is unknown, please follow these guidelines:
  • Obtain a complete history.
  • Perform a complete physical examination or necropsy (depending on the state of the animal).
  • If the animal is alive, collect, freeze, and save:
    • Vomitus (all available)
    • Urine (all available)
    • Whole blood (5 ml in red top clot tube)
    • Whole blood (5 ml in purple top EDTA tube)
    • Serum in glass tube with NO rubber stopper (if zinc toxicity is suspected)
  • If at necropsy:
    • Fix representative tissues in 10% formalin
    • Save samples for bacteriology and virology if appropriate
    • Freeze and save the following for possible toxicology testing:
      • Liver (approximately 100 g)
      • Stomach/rumen contents (approximately 100 g or all available)
      • Brain (if organophosphate toxicosis is suspected) 1/2 brain from large animals; whole brain from small animals
      • Kidney (1/2)
      • Urine (all available)
      • Eyeball or ocular fluid (if nitrate toxicosis is suspected)
  • If feed and/or water are possibly related, submit:
    • A minimum of 1 pound of feed
    • A minimum of 1 quart of water
  • Call the ADDL for consultation on appropriate testing based on the clinical history and physical examination or necropsy findings.